IGLC2 and neoplasm: To validate our MS data by Western Blotting, we chose the protein candidates deleted in malignant brain tumor 1 (DMBT1) and Ig lambda-2 chain C region (IGLC2) based on their abundance in saliva, spectral counts and level of statistical significance in MS data, and the roles of these proteins in immune regulation, epithelial differentiation, tumor suppression, and stress response [25, 26].