In detail, normalization of IR was achieved in 47.2% (25/53, PCOS-exIR) of cases, while two of 36 patients developed IR during the treatment period (5.6%) and 38.2% patients remained insulin sensitive (34/89) and 31.5% remained insulin resistant (28/89, PCOS-PIR), respectively. Here, INS is linked to polycystic ovary syndrome.