In fact, inhibition of mitoBKCa with IbTx reduces the amount of Ca2+ necessary to depolarize brain mitochondria (a measure of increased mPTP activity) (Cheng et al., 2008) and increases cytochrome c release (from GL261 glioma mitochondria), a landmark of mPTP opening and apoptosis (Cheng et al., 2011). The gene discussed is CYCS; the disease is central nervous system cancer.