In acute FITC dermatitis model reduced inflammation, skin eosinophils and mast cells, IL-4, IL-6, TNF, MIP1α, IL-1β, MCP-1, GM-CSF, RANTES, and KC levels No effect in other acute hapten models or in dog In chronic models reduced skin lesions, skin eosinophils and mast cells, IgE, IL-4, IL-5, IL-6, TSLP, TARC, and NGF levels. Here, IGHE is linked to skin disorder.