Evert et al. confirmed these results in their later study and demonstrated that in addition to the Fit-1S and IL-1ra cytokines, IL-6 and two cytokine-inducible transcription factors (C/EBPβ and C/EBPδ) were also upregulated in mutant ataxin-3-expressing cell lines and pontine neurons of SCA3 patients [66]. The gene discussed is ATXN3; the disease is Machado-Joseph disease.