Elevated cytokines, for example, IL-6, IL-8, IL-4, IL-10, TNF-α, and IL-1β [10, 34], and chemokines, for example, eotaxin-3, MIP-1β, eotaxin, MCP-1, and MCP-4 [49], were observed in the plasma of HD patients and mouse models, such as YAC128 [10, 50], R6/2, and Hdh [10, 39] (Supplementary Table 2). This evidence concerns the gene IL1B and Huntington disease.