INS and metabolic dysfunction-associated steatohepatitis: Particularly, the cardiovascular and adipose tissue inflammation in OSAS seems to be related to an enhanced NF-κB activity in endothelial cells, adipose tissue macrophages, and adipocytes [34]; furthermore, NF-κB activation in hepatocytes and in stellate cells is associated with hepatic insulin resistance, hepatocyte apoptosis, and development of NASH and hepatocellular carcinoma in animals and humans [35, 36].