Insulin-resistant ob/ob mice have increased concentrations of SREBP-1c and also develop spontaneous fatty liver [22]: SREBP-1c activates, among other genes, ACC that produces malonyl-CoA, an intermediate in fatty acid synthesis, which inhibits CPT-1, the enzyme transferring fatty acyl-CoAs into the mitochondria for β-oxidation. Here, SREBF1 is linked to Insulin resistance.