CXCR3 receptor is activated by IFN-γ-inducible chemokines such as CXCL9, CXCL10 (IP-10), and CXCL11 (I-TAC), which are highly expressed in atherosclerotic lesions and play an important role in Th1-cell homing. The gene discussed is CXCL10; the disease is Atherosclerotic lesion.