IL18 and infection: Despite its role on resistance of infections, high levels of IL-18 has been related to the pathogenesis of several disorders and diseases, such as Chronic kidney disease (CKD) [30], Atherosclerosis [31–33], Sickle cell anemia (SCA) [34], Acute Myocardial Infarction and Heart Failure [35–37], polycystic ovary syndrome [38], Severe Traumatic Brain Injury [39]; Chronic Obstructive Pulmonary Disease [40], hepatitis C [41], Autoimmune Hepatitis [42], and mainly sepsis, due Melioidosis, an infection caused by the gram-negative bacillus Burkholderia pseudomallei (formerly Pseudomonas) [43].