In this study, to delineate the roles of them in cervical cancer, the levels of sNRP-1 in circulation and NRP-1 protein in the cervical tissues of patients with cervical cancer and cervical intraepithelial neoplasia (CIN) were investigated, to clarify the clinical significance of them as well as the potential diagnostic implication for patients with cervical cancer. This evidence concerns the gene NRP1 and cervical squamous intraepithelial neoplasia.