GPX4 and microcephaly: Interestingly, while GPx4 is expressed in neurons, glial cells are devoid of GPx4 (Savaskan et al., 2007); furthermore, it seems that the developing brain constitutes a major site for GPx4 expression, while the specific suppression of GPx4 between the embryonic Days 7.5 and 10.5 led to microcephaly and abnormal hindbrain development (Borchert et al., 2006).