Three large randomised control trials, Comparison of Age-related Macular Degeneration Treatment Trial (CATT) [6,7], alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularization IVAN [8,9] and Groupe d'Etude Français Avastin versus Lucentis dans la DMLA néovasculaire (GEFAL) [10], have demonstrated non-inferiority of bevacizumab compared to ranibizumab with respect to a non-inferiority margin of five letters. This evidence concerns the gene VEGFA and age-related macular degeneration.