In the present study, we selected 25 tagSNPs of TBX21, GATA3, Rorc and Foxp3. Contrary to previous studies that showed evidence of disease association in Caucasian populations21, 22, 23, 24, no association was found between these 25 SNPs and the susceptibility to BD or VKH syndrome in Han Chinese. The gene discussed is TBX21; the disease is Behcet disease.