As shown in Fig. 3, the mRNA expression levels of RyR2 and SERCA2 were significantly lower in the CHF-SS group compared with the SO-SS group (P<0.000), however, the levels of RyR2 and SERCA2 were increased in the CHF-VNS group compared with the CHF-SS group (P=0.017 and P=0.008, respectively). This evidence concerns the gene ATP2A2 and congestive heart failure.