For instance, we have demonstrated that the depletion of ZEB1 in the resistant pancreatic cancer cell line Panc1 results in re-differentiation and re-sensitization to gemcitabine and that a selection for gemcitabine resistance in the sensitive pancreatic cancer cell line BxPC3 induced an EMT phenotype, with high ZEB1 and low E-cadherin expression (Wellner et al, 2009). This evidence concerns the gene CDH1 and familial pancreatic carcinoma.