The relative mRNA expression of maspin in the glioma tissues of grade I, II, III and IV was 0.83±0.11, 0.76±0.12, 0.51±0.08 and 0.37±0.09, respectively, significantly lower compared to the normal brain tissues (all P<0.05; Fig. 2B). The gene discussed is SERPINB5; the disease is central nervous system cancer.