In the glioma tissue of grade I to IV, the expression of maspin was 2.04±0.32, 1.36±0.3, 0.73±0.25 and 0.42±0.21, respectively, signficantly lower compared to that in the normal brain tissues (all P<0.05; Fig. 3B). This evidence concerns the gene SERPINB5 and central nervous system cancer.