Note, two of the significantly regulated tumour proteins, i.e. CRK and PEBP1 are members of the EGFR1 signalling pathway with PEBP1 also functioning as a master regulator while the other regulated proteins are connected to EGFR signalling through cross-talk among the pathways (see Additional file 15: Table S13). The gene discussed is PEBP1; the disease is neoplasm.