In pursue of tumour growth and to sustain organelle and membrane biogenesis lipids are de novo synthesized and mobilized from stores and while the complex interaction of hepatic lipid and glucose metabolism in liver disease is the subject of intense research [104] the present study evidences significant regulation of several apolipoproteins, i.e. APOE, APOA1, APOA4 and isoforms of albumin. The gene discussed is APOA4; the disease is liver disorder.