As depicted in Figure 8 the proteins of the fusion network displayed functional associations via the EGF/EGFR network and included 69 out of 96 (72%) significantly regulated tumour proteins with 6 out of 7 master regulators being connected to EGFR through the network’s proteins (see Additional file 14: Table S12 for possible protein-protein interactions and related scores). This evidence concerns the gene EGF and neoplasm.