However, apart from alpha-fetoprotein (AFP) only a few serological markers are available in clinical practice (such as Glypican-3, miR-21, fucosylated GP73, α-fucosidase) with AFP diagnostics remaining unsatisfactory because of its low sensitivity and the non-specific correlation between the clinical behavior of HCC and AFP blood levels. The gene discussed is AFP; the disease is hepatocellular carcinoma.