Furthermore, tRNA aminoacylation (AARS, GARS and SARS), advanced glycosylation endproduct receptor signalling (ALB, CAPZA1 and LGALS3), peroxisome (ECH1, HACL1 and SOD1), protein processing in endoplasmic reticulum (GANAB, HYOU1 and PDIA4), proteasome (PSMC5 and PSMD11) and activation of chaperone genes by XBP1(S) and ‘unfolded protein response’ (HYOU1 and LMNA) are pathways significantly perturbed in liver cancer induced by EGF (see Additional file 9: Table S9 and Additional file 10: Table S10). The gene discussed is HYOU1; the disease is liver cancer.