In mouse BMSCs, miR-338-3p that directly affect Runx2 and fibroblast growth factor receptor 2 (Fgfr2) serves as a negative regulator of osteogenic differentiation and may also contribute to osteoporosis, which was shown up-regulated in ovariectomized (OVX) mice compared with sham mice [42]. The gene discussed is FGFR2; the disease is osteoporosis.