We queried The Cancer Genome Atlas (TCGA) ER-positive/HER2-negative breast invasive carcinoma cases 15 using the cBioPortal 16,17 and found that the DNA repair and chromatin remodeling gene alterations identified in our patients’ cancers occurred in 1% to 4% and in 0% to 5% of TCGA cases, respectively. The gene discussed is ERBB2; the disease is invasive breast carcinoma.