TCF12 and Down syndrome: However, three patients reported with a mutation in TCF12 (Family 31, Individual II‐1 in Supplementary Table SIII in Sharma et al. [2013] Probands 1 and 2 in Paumard‐Hernandez et al., 2014) had hearing loss suggesting that hearing loss might be an occasional feature of TCF12‐related syndrome, as it is of other craniosynostosis syndromes.