Thus, we investigated the early, age-dependent APOE genotype-specific effects on cognitive functions and synaptic viability in EFAD-Tg mice [48,58,59], specifically female mice based on data in both humans [53-55] and Tg mice [33,35,36,75,76] that APOE4 females exhibit significantly increased cognitive impairment compared to APOE4 males and APOE3 females. This evidence concerns the gene APOE and Cognitive impairment.