Similarly, Gpx3 (Figure 3B; p = 5 × 10−12 by 3SEQ, p = 6.6 × 10−4 by qPCR), a glutathione peroxidase, is an antioxidant enzyme that acts in fat and glucose metabolism and has been associated with obesity and type 2 diabetes in mouse and human (Lee et al., 2008; Chung et al., 2009). The gene discussed is GPX3; the disease is obesity due to melanocortin 4 receptor deficiency.