Although lncRNAs have been reported to modulate tumor metastasis by mediating the prometastatic role of TGF-β and regulating EMT [22], and several lncRNA transcripts were involved in the biology of carcinogenesis in breast cancer [23–24], the biological roles of lncRNAs in the process of trastuzumab resistance in breast cancer are not well studied. This evidence concerns the gene TGFB1 and neoplasm.