Considering the established role of miR-200c in EMT and trastuzumab resistance in breast cancer, we could conclude lnc-ATB which is activated by TGF-β modulate the process of trastuzumab resisitance and metastasis in HER2 positve breast cancer by regulating the miR200c/ZEB1 and miR-200c/ZNF217 signaling pathway. Here, TGFB1 is linked to breast carcinoma.