In the current study, we reported that lnc-ATB, which had been reported to be activated by TGF-β, promote trastuzumab resistance and invasion-metastasis cascade in breast cancer by competitively biding miR-200c, up-regulating ZEB1 and ZNF-217, and then inducing EMT (Figure 6E). Here, TGFB1 is linked to breast cancer.