Targeting EGFR with antibodies that block binding of natural ligands to the receptor or with small-molecule compounds that specifically inhibit activation of the receptor tyrosine kinase has shown clinical activity, which led to regulatory approval of EGFR-targeted therapy for patients with metastatic cancers of the colon, head and neck, or lungs [2, 3]. Here, EGFR is linked to metastatic malignant neoplasm.