HIF1A and cancer: Hypoxia-inducible factor-1 (HIF-1), a key transcription factor regulating glycolysis, plays a critical role in reprogramming cancer metabolism in favor of aerobic glycolysis (i.e., the Warburg effect), through which large amounts of biomass and reducing equivalents in the form of NADPH are generated to support unlimited proliferation of cancer cells [14, 15].