This study is a follow-up to our recent work reporting that cetuximab exerts its antitumor activity in part via reversing the Warburg effect in cancer cells [18] and our earlier work reporting that cetuximab can downregulate HIF-1α and that downregulation of HIF-1α is required for cetuximab-induced antitumor activities [16, 17]. The gene discussed is HIF1A; the disease is cancer.