To examine the role of the β-catenin/TCF complex in doxorubicin-induced EMT, the expression of β-catenin, EMT-markers and interaction of TCF4 with β-catenin in HCC cells treated with doxorubicin in the presence or absence of PKF 118-310, a small-molecule antagonist of the β-catenin/TCF4 complex [28], was assessed. Here, HNF4A is linked to hepatocellular carcinoma.