Markedly decreased phosphorylation of Y1068, one of the major autophosphorylation sites on EGFR, in cetuximab-IONP-treated N08-30 and N08-1002 neurospheres (Figure 1D) confirm the biological activity of cetuximab-IONPs on EGFR signaling in GBM neurospheres. Here, EGFR is linked to glioblastoma.