The frequency distribution of sortilin levels (Fig. 2) showed that the majority of normal tissues had low levels of sortilin (staining intensity 0 and 1), while the proportion of cases with intermediate (staining intensity 2) and high (staining intensity 3) levels of sortilin increased in cancers and in particular in invasive ductal carcinomas (IDC) and lymph node positive tumors. The gene discussed is SORT1; the disease is cancer.