In both PTEN deleted (Jurkat and Loucy) and PTEN non deleted (DND-41 and ALL-SIL) cells, growth rate decreased after treatment with BKM-120 and ZSTK-474 with IC50 values ranging between 1.05–2.34 μM for BKM-120 and 0.99–3.39 μM for ZSTK-474. The gene discussed is PTEN; the disease is acute lymphoblastic leukemia.