Increase of these transcripts appeared to be cell type-dependent, as ALL-SIL, DND-41 and, partially, Loucy cells, which activated autophagy after PI3K pan-inhibition, up-regulated numerous genes involved in the formation of autophagosomes (DRAM1, GABARAPL1, GABARAPL2, MAP1LC3B, ATG16L2, WIPI1, PIK3C3), as well as anti-apoptotic genes (BCL2) and genes of the unfolded protein response signaling (EIF2AK3). Here, PIK3CA is linked to acute lymphoblastic leukemia.