Fucoxanthin increased High-Density Lipoprotein (HDL)-cholesterol and non-HDL-cholesterol levels in KK-Ay mice (a type 2 diabetic knock-out mouse model that exhibits marked obesity, glucose intolerance, severe insulin resistance, dyslipidemia, and hypertension) by inducing Sterol Regulatory Element-Binding Protein (SREBP) expression and reduced cholesterol uptake in the liver, via down-regulation of Low-Density Lipoprotein (LDL)-receptor and (Scavenger Receptor class B member 1) SR-B1. This evidence concerns the gene SCARB1 and type 2 diabetes mellitus.