Hence, UCP1 gene is implicated in the development of these disorders: several studies have reported that polymorphisms -3826A/G, -1766A/G and -112A/C in its promoter region, Ala64Thr in exon 2 and Met299Leu in exon 5 are possibly associated with obesity [58]. The gene discussed is UCP1; the disease is obesity due to melanocortin 4 receptor deficiency.