Maeda et al. reported that increased mRNA expression of monocyte chemoattractant protein-1 (MCP-1) was observed in high fat (HF) mice, but was normalized in the fucoxanthin-rich lipids (FLs) group: the HF-FL diet could suppress high fat (HF) diet-induced obesity in mice [27]. Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.