NF-κB regulates the expression of enzymes (such as COX-2 and iNOS), cytokines (such as TNF, IL-1, IL-6, IL-8), adhesion molecules and has been linked with age-related diseases such as atherosclerosis, diabetes, osteoporosis, Alzheimer’s disease, and cancer [64]. The gene discussed is PTGS2; the disease is osteoporosis.