LY294002 pretreatment largely reversed the protective effect of ATX on renal tubular apoptosis after burns in rats, as well as the expression of signals in the mitochondrial-dependent pathway, which supported our deduction about the implication of the Akt/Bad/Caspase signalling cascade in the nephroprotection of ATX in early AKI secondary to severe burns. Here, AKT1 is linked to acute kidney injury.