Since both of two candidate genes in this research involve in expression regulation of some testis specific and important genes such as PRM1, PRM2, TNP1, TNP2, etc., different studies have pointed out that targeting YBX2 and JHDM2A genes in animal models causes male infertility and different degrees of impaired spermatogenesis. The gene discussed is KDM3A; the disease is male infertility.