Studies showed that PPARγ ligands which included15-deoxy-Δ12, 14-prostaglandin J2, rosiglitazone and the novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induced apoptosis in myeloid (U937 and HL-60) and lymphoid (Su-DHL, Sup-M2, Ramos, Raji, Hodgkin’s cell lines, and primary chronic lymphocytic leukemia) cells. This evidence concerns the gene PPARG and B-cell chronic lymphocytic leukemia.