Another study examined epigenome-wide methylations in blood from twins discordant for T2D, that were followed up with replication and omics analyses, and identified DNA methylation alterations in MALT1 (which has a role in the nuclear factor-κB pathway) as well as the G-protein receptor 6 gene (GPR61), that were suggested to reflect T2D progression (61). This evidence concerns the gene MALT1 and type 2 diabetes mellitus.