FXR dysfunction contributes to many diseases, such as hepatic tumorigenesis (Kim et al., 2007b; Yang et al., 2007), intestinal diseases (Kim et al., 2007a), cholestasis (Stedman et al., 2006), atherosclerosis (Guo et al., 2006), and impaired liver regeneration (Huang et al., 2006; Fan et al., 2015). Here, NR1H4 is linked to atherosclerosis.