INS and Insulin resistance: The decrease of both basal glucose and insulin levels in plasma resulted in reduced values of the Homeostatic Model Assessment (HOMA)-IR [F(2, 15) = 8.44, **P < 0.01], defined as an index for insulin resistance, as well as increased values of HOMA-β [F(2, 15) = 7.74, **P < 0.01], defined as an index for beta-cell function, in the rats acutely and repeatedly treated with URB597 (Table 1).