MCPH1 and microcephaly: Futher approaches may be to generate humanized and primatized mice expressing human and other primate MCPH1 (Pulvers et al., 2010), or the use of cerebral organoids (Lancaster et al., 2013), an in vitro model of human cortical development, where microcephaly-causing mutations in humans and primate-specific variants in MCPH1 can be investigated in detail in a system amenable to experimentation (Enard, 2014).