For example, while c-Myc has been shown to activate hTERT transcription in cancer cells and some normal cells [235], moderate overexpression of c-Myc by itself is not sufficient for activation of endogenous hTERT genes in normal human mammary epithelial cells [191]; in the latter case, additional genomic alterations were needed for telomerase activation and cellular immortalization. The gene discussed is MYC; the disease is cancer.