EZH2 and neoplasm: Many studies have characterized the expression profiles of miRNAs in various tumor types; for example, miR-200c modulates epithelial-to-mesenchymal transition in human colorectal cancer [13], and miR-137 is down-regulated in glioblastoma and inhibits the stemness of glioma by directly repressing RTVP-1 [14], microRNA-218 functions as a tumor suppressor in head and neck squamous cell carcinoma via inhibiting cell migration and invasion [15], Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma [16].