Pre-treatment of cells with MG-132 inhibited the proteosomal degradation of β-catenin, which in turn increased the expression of downstream molecules such as cyclin D1 and c-Myc in PanC-1 and MiaPaCa-2 cells (Figure 4A & 4B), suggesting that capsaicin treatment increases proteosomal degradation of β-catenin and thereby inhibits β-catenin/TCF-1 signaling in pancreatic cancer cells. This evidence concerns the gene CCND1 and familial pancreatic carcinoma.