In line with our observations showing that ALDH1A3 is STAT3 target, it is intriguing to observe how the metabolic phenotype of the ALDH1A3 expressing glioma cells, consisting of aerobic glycolysis, is similar to that of cells expressing a transforming version of the STAT3 protein with increased nuclear retention and transcriptional activity [19, 53]. This evidence concerns the gene ALDH1A3 and central nervous system cancer.