ALDH1A3 and central nervous system cancer: The STAT3 pathway may modulate the number of NSCLC- and mesothelioma- ALDHbright cells [4, 30] and, notably, glioma cells of the mesenchymal subtype, which require STAT3 (and CEBPβ) for their survival [31], exhibited high levels of ALDH1A3 expression [19].