Knockdown of SOX17 also induced EMT in CRC cells by activating Wnt/β-catenin signaling, as shown by the morphological changes (Supplementary Figure 4B), up-regulations of Vimentin and Slug, down-regulation of E-cadherin (Figure 3D and 3E), nuclear translocation of β-catenin (Figure 3E), TCF/LEF transcriptional activation (Supplementary Figure 4C) and increased expression of target genes CyclinD1, C-myc and DKK1 (Figure 3D). The gene discussed is SOX17; the disease is colorectal carcinoma.