CCNE1 and breast carcinoma: In addition, breast cancer cell lines derived from TNBC patients (MDA-MB-468, MDA-MB-231) showed (a) higher incidence and severity of centrosome amplification (Fig. 3Ci, ii) (b) elevated expression of centrosomal (pericentrin, centrin-2, γ-tubulin) and centrosome amplification markers (Plk4 and cyclin E), compared to non-TNBC-derived (MCF-7) lines (Fig. 3B).