PNPLA2 and obesity due to melanocortin 4 receptor deficiency: We identified 35 genes from this module in the genetic association database, including genes associated with type 2 diabetes, obesity, and insulin resistance (i.e. PNPLA2, SOD2, ZNF716, VAMP3, SHC1, IL18, DLC1, CYFIP1, and ASPSCR1).