PTK2 and posterior cortical atrophy: Autophosphorylation of FAK leads to association with multiple Src family kinases [43, 59], which are themselves constitutively activated in progressive stages of PCa [34, 45], and are responsible for phosphorylation of tyrosine residues on FAK that derepress FAK adaptor functions leading to aberrant activation of signaling cascades that increase metastatic potential.