When patients were classified by the RPA in each subtype, genetic factors contributed significantly to differentiating the high risk group associated with DFS inbreast cancer, specifically the HR+ HER2- (Pdiscovery=1.18×10-8 and Preplication=2.08×10-5) and HR- HRE2- subtypes (Pdiscovery=2.35×10-4 and Preplication=2.60×10-2). Here, ERBB2 is linked to cancer.