In combined analyses of the discovery and replication sets, those two SNPs had strong associations among breast cancer patients for each subtype (HRrs166870 = 2.30, 95% CI = 1.67–3.15, ptrend = 2.88×10-7 in HR+ HER2- and HRrs10825036 = 2.26, 95% CI = 1.34–3.81, ptrend = 3.54×10-7 in HR- HER2-, Table 2). The gene discussed is ERBB2; the disease is breast carcinoma.