Among other adhesion molecules, PSGL-1 was identified also in human primary t(8;21)+ AML patient samples (see Supplementary Figure 4).31, 35 As RE has been shown to induce epigenetic changes to repress its target genes,31 we examined the RE-binding sites for the presence of several active and repressive histone marks including the repressive H3K27me3 chromatin mark. This evidence concerns the gene SELPLG and acute myeloid leukemia.