PSGL-1 was also identified as a potential RE target via genome-wide chromatin immunoprecipitation (ChIP)-sequencing experiments with Kasumi-1 cells and t(8;21)+ patient material.31 In agreement with our observations, a publically available gene array database has revealed low PSGL-1 expression levels in t(8;21)+ primary leukemic cells compared with healthy counterparts (Figure 1c).32 A further analysis of a large AML gene array data set categorized by karyotypes also revealed low PSGL-1 expression in t(8;21)+ samples (Figure 1d). The gene discussed is SELPLG; the disease is acute myeloid leukemia.