Drugs targeting the PD-1/PDL-1 pathway such as nivolumab (a blocking antibody against PD-1), pembrolizumab (anti-PD-1 antibody) and BMS-936559 (anti-PDL-1 antibody) have been used in other cancers and may be used to treat MCC [211]. The gene discussed is CD274; the disease is Merkel cell skin cancer.