For example, Taci−/− mice and BAFF transgenic mice both develop symptoms of SLE-like autoimmune diseases [7–10], which indicates that although a loss of TACI signaling contributes to the incidence of autoimmune diseases, an increase in TACI signaling due to elevated BAFF level fails to prevent the occurrence of autoimmune diseases. Here, TNFSF13B is linked to systemic lupus erythematosus.