TNFRSF13B and systemic lupus erythematosus: For example, Taci−/− mice and BAFF transgenic mice both develop symptoms of SLE-like autoimmune diseases [7–10], which indicates that although a loss of TACI signaling contributes to the incidence of autoimmune diseases, an increase in TACI signaling due to elevated BAFF level fails to prevent the occurrence of autoimmune diseases.