Only a few studies with large-scale patient databases exist, such as the ORIGIN trial which enrolled 12,537 patients and followed them for 6.2 years (interquartile range, 5.8–6.7 years) and showed no statistically significant association between cancer risk and insulin glargine use; however, these results may be due to very well-controlled glucose levels, as well as the inclusion of prediabetic patients [9, 164]. The gene discussed is INS; the disease is cancer.