Furthermore, with greater understanding of the intracellular sites of cysLT synthesis and cysLTR expression and of the functional consequences of such cysLTR-mediated cellular regulation for both intracellular and cell-free granules, newer therapeutic agents may be targeted to regulate specific activities of cysLTs pertinent to asthma and other allergic diseases. The gene discussed is CYSLTR1; the disease is allergic disease.